| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C theta type |
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| Ligand | BDBM25558 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_523117 (CHEMBL1007475) |
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| IC50 | 70±n/a nM |
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| Citation |  Boschelli, DH; Wang, D; Prashad, AS; Subrath, J; Wu, B; Niu, C; Lee, J; Yang, X; Brennan, A; Chaudhary, D Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCtheta inhibitors. Bioorg Med Chem Lett19:3623-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C theta type |
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| Name: | Protein kinase C theta type |
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| Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 81878.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length human PKC theta (Panvera Catalog No. P2996). |
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| Residue: | 706 |
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| Sequence: | MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
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| BDBM25558 |
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| n/a |
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| Name | BDBM25558 |
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| Synonyms: | 4-arylamino-3-pyridinecarbonitrile, 4p | 5-(3,4-dimethoxyphenyl)-4-(1H-indol-5-ylamino)pyridine-3-carbonitrile | BMCL192461 Compound 1a | CHEMBL492251 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18N4O2 |
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| Mol. Mass. | 370.4039 |
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| SMILES | COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1 |
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| Structure | 
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