| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein |
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| Ligand | BDBM50208940 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_523531 (CHEMBL1000653) |
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| IC50 | 80±n/a nM |
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| Citation |  Im, I; Lee, ES; Choi, SJ; Lee, JY; Kim, YC Structure-activity relationships of heteroaromatic esters as human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett19:3632-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein |
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| Name: | Genome polyprotein |
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| Synonyms: | POLG_HRV16 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 242260.90 |
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| Organism: | Human rhinovirus 16 |
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| Description: | ChEMBL_523531 |
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| Residue: | 2153 |
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| Sequence: | MGAQVSRQNVGTHSTQNMVSNGSSLNYFNINYFKDAASSGASRLDFSQDPSKFTDPVKDV
LEKGIPTLQSPSVEACGYSDRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDATAID
KPTQPDTSSNRFYTLDSKMWNSTSKGWWWKLPDALKDMGIFGENMFYHFLGRSGYTVHVQ
CNASKFHQGTLLVVMIPEHQLATVNKGNVNAGYKYTHPGEAGREVGTQVENEKQPSDDNW
LNFDGTLLGNLLIFPHQFINLRSNNSATLIVPYVNAVPMDSMVRHNNWSLVIIPVCQLQS
NNISNIVPITVSISPMCAEFSGARAKTVVQGLPVYVTPGSGQFMTTDDMQSPCALPWYHP
TKEIFIPGEVKNLIEMCQVDTLIPINSTQSNIGNVSMYTVTLSPQTKLAEEIFAIKVDIA
SHPLATTLIGEIASYFTHWTGSLRFSFMFCGTANTTLKVLLAYTPPGIGKPRSRKEAMLG
THVVWDVGLQSTVSLVVPWISASQYRFTTPDTYSSAGYITCWYQTNFVVPPNTPNTAEML
CFVSGCKDFCLRMARDTDLHKQTGPITQNPVERYVDEVLNEVLVVPNINQSHPTTSNAAP
VLDAAETGHTNKIQPEDTIETRYVQSSQTLDEMSVESFLGRSGCIHESVLDIVDNYNDQS
FTKWNINLQEMAQIRRKFEMFTYARFDSEITMVPSVAAKDGHIGHIVMQYMYVPPGAPIP
TTRDDYAWQSGTNASVFWQHGQPFPRFSLPFLSIASAYYMFYDGYDGDTYKSRYGTVVTN
DMGTLCSRIVTSEQLHKVKVVTRIYHKAKHTKAWCPRPPRAVQYSHTHTTNYKLSSEVHN
DVAIRPRTNLTTVGPSDMYVHVGNLIYRNLHLFNSDIHDSILVSYSSDLIIYRTSTQGDG
YIPTCNCTEATYYCKHKNRYYPINVTPHDWYEIQESEYYPKHIQYNLLIGEGPCEPGDCG
GKLLCKHGVIGIITAGGEGHVAFIDLRHFHCAEEQGITDYIHMLGEAFGSGFVDSVKDQI
NSINPINNISSKMVKWMLRIISAMVIIIRNSSDPQTIIATLTLIGCNGSPWRFLKEKFCK
WTQLTYIHKESDSWLKKFTEMCNAARGLEWIGNKISKFIDWMKSMLPQAQLKVKYLSELK
KLNFLEKQVENLRAADTNTQEKIKCEIDTLHDLSCKFLPLYASEAKRIKVLYHKCTNIIK
QKKRSEPVAVMIHGPPGTGKSITTSFLARMITNESDIYSLPPDPKYFDGYDNQSVVIMDD
IMQNPGGEDMTLFCQMVSSVTFIPPMADLPDKGKPFDSRFVLCSTNHSLLAPPTISSLPA
MNRRFYLDLDILVHDNYKDNQGKLDVSRAFRLCDVDSKIGNAKCCPFVCGKAVTFKDRNT
CRTYSLSQIYNQILEEDKRRRQVVDVMSAIFQGPISMDKPPPPAITDLLRSVRTPEVIKY
CQDNKWIVPADCQIERDLNIANSIITIIANIISIAGIIYIIYKLFCSLQGPYSGEPKPKT
KVPERRVVAQGPEEEFGMSIIKNNTCVVTTTNGKFTGLGIYDRILILPTHADPGSEIQVN
GIHTKVLDSYDLFNKEGVKLEITVLKLDRNEKFRDIRKYIPESEDDYPECNLALVANQTE
PTIIKVGDVVSYGNILLSGTQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGF
SSMLLRSYFTEQQGQIQISKHVKDVGLPSIHTPTKTKLQPSVFYDIFPGSKEPAVLTEKD
PRLKVDFDSALFSKYKGNTECSLNEHIQVAVAHYSAQLATLDIDPQPIAMEDSVFGMDGL
EALDLNTSAGYPYVTLGIKKKDLINNKTKDISKLKLALDKYDVDLPMITFLKDELRKKDK
IAAGKTRVIEASSINDTILFRTVYGNLFSKFHLNPGVVTGCAVGCDPETFWSKIPLMLDG
DCIMAFDYTNYDGSIHPIWFKALGMVLDNLSFNPTLINRLCNSKHIFKSTYYEVEGGVPS
GCSGTSIFNSMINNIIIRTLVLDAYKHIDLDKLKIIAYGDDVIFSYKYKLDMEAIAKEGQ
KYGLTITPADKSSEFKELDYGNVTFLKRGFRQDDKYKFLIHPTFPVEEIYESIRWTKKPS
QMQEHVLSLCHLMWHNGPEIYKDFETKIRSVSAGRALYIPPYELLRHEWYEKF
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| BDBM50208940 |
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| n/a |
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| Name | BDBM50208940 |
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| Synonyms: | 5-bromo-pyridin-3-yl furan-2-carboxylate | 5-bromopyridin-3-yl furan-2-carboxylate | CHEMBL222234 | acs.jmedchem.1c00409_ST.37 | jm5b01461, Compound 121 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H6BrNO3 |
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| Mol. Mass. | 268.064 |
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| SMILES | Brc1cncc(OC(=O)c2ccco2)c1 |
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| Structure | 
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