Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1A

Ligand

BDBM50030026

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_201036 (CHEMBL803262)

1.5±n/a nM

Citation

Liu, Y; Svensson, BE; Yu, H; Cortizo, L; Ross, SB; Lewander, T; Hacksell, U C8-substituted derivatives of 2-(dipropylamino)tetralin: Palladium-catalyzed synthesis and interactions with 5-HT_1A-receptors Bioorg Med Chem Lett1:257-262 (1991) Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1A

Name:

5-hydroxytryptamine receptor 1A

Synonyms:

5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

46445.29

Organism:

Rattus norvegicus (rat)

Description:

Binding assays were performed using rat hippocampal membranes.

Residue:

422

Sequence:

MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR

BDBM50030026

n/a

Name

BDBM50030026

Synonyms:

((R)-8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine | ((R)-8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-ammonium | (8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine | CHEMBL90053

Type

Small organic molecule

Emp. Form.

C17H27NO

Mol. Mass.

261.4024

SMILES

CCCN(CCC)[C@@H]1CCc2cccc(OC)c2C1

Structure