| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50283168 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_35253 |
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| IC50 | 10±n/a nM |
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| Citation |  Olson, RE; Liu, J; Lalka, GK; VanAtten, MK; Wexler, RR; Chiu, AT; Nguyen, TT; McCall, DE; Wong, PC; Timmermans, PB Balanced angiotensin II receptor antagonists. II.1,2 4-aminomethyl- and acylaminomethylimidazoles Bioorg Med Chem Lett4:2229-2234 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1) |
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| Type: | Protein |
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| Mol. Mass.: | 41080.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30556 |
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| Residue: | 359 |
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| Sequence: | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
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| BDBM50283168 |
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| n/a |
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| Name | BDBM50283168 |
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| Synonyms: | 3-[2'-(Cyclopropanecarbonyl-sulfamoyl)-biphenyl-4-ylmethyl]-2-propyl-5-(4-pyridin-2-yl-piperazin-1-ylmethyl)-3H-imidazole-4-carboxylic acid | CHEMBL409170 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H38N6O5S |
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| Mol. Mass. | 642.768 |
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| SMILES | CCCc1nc(CN2CCN(CC2)c2ccccn2)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1 |
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| Structure | 
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