| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50101498 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_101760 |
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| Ki | 25000±n/a nM |
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| Citation |  Morphy, JR; Beeley, NR; Boyce, BA; Leonard, J; Mason, B; Millican, A; Millar, K; O'Connell, JP; Porter, J Potent and selective inhibitors of gelatinase-A 2. carboxylic and phosphonic acid derivatives Bioorg Med Chem Lett4:2747-2752 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50101498 |
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| n/a |
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| Name | BDBM50101498 |
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| Synonyms: | CHEMBL74977 | [(S)-2-((S)-2-Cyclohexyl-1-phenethylcarbamoyl-ethylcarbamoyl)-5-phenyl-pentyl]-phosphonic acid | [2-(2-Cyclohexyl-1-phenethylcarbamoyl-ethylcarbamoyl)-5-phenyl-pentyl]-phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C29H41N2O5P |
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| Mol. Mass. | 528.62 |
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| SMILES | OP(O)(=O)C[C@@H](CCCc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)C(=O)NCCc1ccccc1 |
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| Structure | 
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