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Reaction Details
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TargetNeutrophil elastase
LigandBDBM50284214
Substrate/Competitorn/a
Meas. Tech.ChEBML_86533
IC50 92000±n/a nM
Citation Player, MRSr., JSPatil, GSChih-Min, KPowers, JC 1,3-Oxazino[4,5-b]indole-2,4-(1H,9H)-diones and 5,6-dimethylpyrrolo-[2,3-d]-1,3-oxazin-2,4-(1H,7H)-diones as serine protease inhi... Bioorg Med Chem Lett4:949-954 (1994)    Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50284214
n/a
NameBDBM50284214
Synonyms:Acetic acid 2,4-dioxo-9-phenethyl-1,2,4,9-tetrahydro-[1,3]oxazino[4,5-b]indol-6-yl ester | CHEMBL174436
TypeSmall organic molecule
Emp. Form.C20H16N2O5
Mol. Mass.364.3514
SMILESCC(=O)Oc1ccc2n(CCc3ccccc3)c3nc(=O)oc(O)c3c2c1
Structure
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