| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50284961 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_138955 |
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| Ki | 4100±n/a nM |
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| Citation |  Wu, ES; Mack, RA; Kover, A; Loch, JT; Mullen, G; Murray, RJ; Gordon, JC; Machulskis, AC; McCreedy, SA; Blosser, JC Synthesis and biological activity of enantiomers of a conformationally restricted muscarone analog Bioorg Med Chem Lett5:1813-1818 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51390.46 |
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| Organism: | RAT |
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| Description: | P08482 |
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| Residue: | 460 |
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| Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50284961 |
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| n/a |
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| Name | BDBM50284961 |
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| Synonyms: | (S)-2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one | CHEMBL50898 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H17NO2 |
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| Mol. Mass. | 183.2475 |
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| SMILES | C[C@@H]1OC2(CC1=O)CCN(C)CC2 |
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| Structure | 
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