| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50286139 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_101746 |
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| IC50 | 30±n/a nM |
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| Citation |  Hughes, I; Harper, GP; Karran, EH; Markwell, RE; Miles-Williams, AJ Synthesis of thiophenol derivatives as inhibitors of human collagenase Bioorg Med Chem Lett5:3039-3042 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50286139 |
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| n/a |
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| Name | BDBM50286139 |
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| Synonyms: | (S)-2-(2-Mercapto-benzyl)-4-methyl-pentanoic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide | CHEMBL103957 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N2O2S |
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| Mol. Mass. | 398.562 |
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| SMILES | CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)Cc1ccccc1S |
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| Structure | 
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