| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysosomal acid glucosylceramidase |
|---|
| Ligand | BDBM50288854 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_215889 |
|---|
| IC50 | >1000000±n/a nM |
|---|
| Citation |  Igarashi, Y; Ichikawa, M; Ichikawa, Y Synthesis of a new inhibitor of α-fucosidase Bioorg Med Chem Lett6:553-558 (1996) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysosomal acid glucosylceramidase |
|---|
| Name: | Lysosomal acid glucosylceramidase |
|---|
| Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 59724.64 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
|---|
| Residue: | 536 |
|---|
| Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
|
|
|
|---|
| BDBM50288854 |
|---|
| n/a |
|---|
| Name | BDBM50288854 |
|---|
| Synonyms: | 5-Methylene-piperidine-3,4-diol | CHEMBL150938 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H11NO2 |
|---|
| Mol. Mass. | 129.157 |
|---|
| SMILES | OC1CNCC(=C)C1O |
|---|
| Structure | 
|
|---|
Search and Browse
