| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50289167 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_36930 |
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| IC50 | 8.8±n/a nM |
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| Citation |  de Laszlo, SE; Glinka, TW; Greenlee, WJ; Ball, R; Nachbar, RB; Prendergast, K The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists Bioorg Med Chem Lett6:923-928 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41009.15 |
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| Organism: | RABBIT |
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| Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
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| Residue: | 359 |
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| Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
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| BDBM50289167 |
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| n/a |
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| Name | BDBM50289167 |
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| Synonyms: | 4'-[6-(3-Isopropyl-ureido)-4-oxo-2-propyl-4H-quinazolin-3-ylmethyl]-biphenyl-2-sulfonic acid acetyl-amide | CHEMBL173455 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33N5O5S |
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| Mol. Mass. | 575.679 |
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| SMILES | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(C)=O |
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| Structure | 
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