| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
|---|
| Ligand | BDBM50289168 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_36930 |
|---|
| IC50 | 0.400000±n/a nM |
|---|
| Citation |  de Laszlo, SE; Glinka, TW; Greenlee, WJ; Ball, R; Nachbar, RB; Prendergast, K The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists Bioorg Med Chem Lett6:923-928 (1996) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Type-1 angiotensin II receptor |
|---|
| Name: | Type-1 angiotensin II receptor |
|---|
| Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 41009.15 |
|---|
| Organism: | RABBIT |
|---|
| Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
|---|
| Residue: | 359 |
|---|
| Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
|
|
|
|---|
| BDBM50289168 |
|---|
| n/a |
|---|
| Name | BDBM50289168 |
|---|
| Synonyms: | CHEMBL173643 | N-{4-Oxo-2-propyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,4-dihydro-quinazolin-6-yl}-benzamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H27N7O2 |
|---|
| Mol. Mass. | 541.6025 |
|---|
| SMILES | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
