| Reaction Details |
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 | Report a problem with these data |
| Target | D(2) dopamine receptor |
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| Ligand | BDBM50240701 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_60237 |
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| Ki | 9±n/a nM |
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| Citation |  Calligaro, DO; Fairhurst, J; Hotten, TM; Moore, NA; Tupper, DE The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053) Bioorg Med Chem Lett7:25-30 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(2) dopamine receptor |
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| Name: | D(2) dopamine receptor |
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| Synonyms: | D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2 |
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| Type: | Cell-surface receptors |
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| Mol. Mass.: | 50647.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14416 |
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| Residue: | 443 |
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| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC
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| BDBM50240701 |
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| n/a |
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| Name | BDBM50240701 |
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| Synonyms: | 2-Methyl-10-piperazin-1-yl-4H-3-thia-4,9-diaza-benzo[f]azulene | 4-Desmethylolanzapine | CHEMBL1125 | desmethylolanzapine | olanzapine, N-desmethyl |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N4S |
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| Mol. Mass. | 298.406 |
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| SMILES | Cc1cc2c(Nc3ccccc3N=C2N2CCNCC2)s1 |c:13| |
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| Structure | 
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