| Reaction Details |
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 | Report a problem with these data |
| Target | Excitatory amino acid transporter 1 |
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| Ligand | BDBM50292997 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_496048 (CHEMBL998478) |
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| IC50 | 120±n/a nM |
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| Citation |  Jensen, AA; Erichsen, MN; Nielsen, CW; Stensbøl, TB; Kehler, J; Bunch, L Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1. J Med Chem52:912-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Excitatory amino acid transporter 1 |
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| Name: | Excitatory amino acid transporter 1 |
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| Synonyms: | EAA1_HUMAN | EAAT1 | Excitatory Amino Acid EAAT1 | GLAST | GLAST1 | SLC1A3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59577.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Excitatory Amino Acid EAAT1 0 HUMAN::P43003 |
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| Residue: | 542 |
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| Sequence: | MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET
KM
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| BDBM50292997 |
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| n/a |
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| Name | BDBM50292997 |
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| Synonyms: | 2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile | CHEMBL474133 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H22N2O3 |
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| Mol. Mass. | 422.4752 |
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| SMILES | COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12 |c:16| |
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| Structure | 
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