| Reaction Details |
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 | Report a problem with these data |
| Target | DNA (cytosine-5)-methyltransferase 3B |
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| Ligand | BDBM50294556 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_575600 (CHEMBL1036445) |
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| IC50 | 27000±n/a nM |
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| Citation |  Isakovic, L; Saavedra, OM; Llewellyn, DB; Claridge, S; Zhan, L; Bernstein, N; Vaisburg, A; Elowe, N; Petschner, AJ; Rahil, J; Beaulieu, N; Gauthier, F; MacLeod, AR; Delorme, D; Besterman, JM; Wahhab, A Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. Bioorg Med Chem Lett19:2742-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA (cytosine-5)-methyltransferase 3B |
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| Name: | DNA (cytosine-5)-methyltransferase 3B |
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| Synonyms: | DNM3B_HUMAN | DNMT3B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95771.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1473708 |
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| Residue: | 853 |
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| Sequence: | MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
HLFAPLKDYFACE
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| BDBM50294556 |
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| n/a |
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| Name | BDBM50294556 |
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| Synonyms: | (2S,3R,4S,5S)-2-(6-(2-(biphenyl-4-yl)ethylamino)-2-chloro-9H-purin-9-yl)-5-(((S)-pyrrolidin-3-ylthio)methyl)tetrahydrofuran-3,4-diol | CHEMBL560768 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H31ClN6O3S |
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| Mol. Mass. | 567.102 |
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| SMILES | O[C@@H]1[C@@H](CS[C@H]2CCNC2)O[C@H]([C@@H]1O)n1cnc2c(NCCc3ccc(cc3)-c3ccccc3)nc(Cl)nc12 |r| |
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| Structure | 
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