Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | DNA (cytosine-5)-methyltransferase 3B |
---|
Ligand | BDBM50294569 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_575600 (CHEMBL1036445) |
---|
IC50 | 21000±n/a nM |
---|
Citation | Isakovic, L; Saavedra, OM; Llewellyn, DB; Claridge, S; Zhan, L; Bernstein, N; Vaisburg, A; Elowe, N; Petschner, AJ; Rahil, J; Beaulieu, N; Gauthier, F; MacLeod, AR; Delorme, D; Besterman, JM; Wahhab, A Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. Bioorg Med Chem Lett19:2742-6 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
DNA (cytosine-5)-methyltransferase 3B |
---|
Name: | DNA (cytosine-5)-methyltransferase 3B |
Synonyms: | DNM3B_HUMAN | DNMT3B |
Type: | PROTEIN |
Mol. Mass.: | 95771.12 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1473708 |
Residue: | 853 |
Sequence: | MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
HLFAPLKDYFACE
|
|
|
BDBM50294569 |
---|
n/a |
---|
Name | BDBM50294569 |
Synonyms: | (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-(((R)-pyrrolidin-2-ylmethylthio)methyl)tetrahydrofuran-3,4-diol | CHEMBL562689 |
Type | Small organic molecule |
Emp. Form. | C15H22N6O3S |
Mol. Mass. | 366.439 |
SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CSC[C@H]2CCCN2)[C@@H](O)[C@H]1O |r| |
Structure |
|