Reaction Details | |||
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Target | Proto-oncogene Wnt-3 | ||
Ligand | BDBM50294821 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_576549 (CHEMBL1032002) | ||
EC50 | >25000±n/a nM | ||
Citation | Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett19:3825-7 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Proto-oncogene Wnt-3 | |||
Name: | Proto-oncogene Wnt-3 | ||
Synonyms: | INT4 | Proto-oncogene protein Wnt-3 | WNT3 | WNT3_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 39653.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_576549 | ||
Residue: | 355 | ||
Sequence: |
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BDBM50294821 | |||
n/a | |||
Name | BDBM50294821 | ||
Synonyms: | 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-3-methyl-N-quinolin-8-yl-benzamide | CHEMBL559290 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H21N3O3 | ||
Mol. Mass. | 423.4632 | ||
SMILES | Cc1cc(ccc1-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O)C(=O)Nc1cccc2cccnc12 |r,wU:13.13,11.12,c:15,(-4.62,-35.31,;-3.86,-36.65,;-2.32,-36.66,;-1.55,-37.99,;-2.32,-39.33,;-3.86,-39.33,;-4.63,-37.99,;-6.17,-37.98,;-7.08,-39.24,;-6.61,-40.71,;-8.55,-38.76,;-9.9,-39.42,;-9.48,-37.94,;-9.87,-36.45,;-11.21,-37.21,;-11.21,-38.75,;-8.55,-37.22,;-7.08,-36.75,;-6.61,-35.28,;-.01,-38,;.76,-36.67,;.76,-39.34,;2.3,-39.3,;3.04,-37.95,;4.57,-37.9,;5.38,-39.21,;4.64,-40.58,;5.44,-41.88,;4.71,-43.23,;3.17,-43.28,;2.37,-41.96,;3.1,-40.61,)| | ||
Structure |