Ki Summary

Reaction Details

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Target

Proto-oncogene Wnt-3

Ligand

BDBM50294822

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_576549 (CHEMBL1032002)

EC50

>25000±n/a nM

Citation

Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett19:3825-7 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Proto-oncogene Wnt-3

Name:

Proto-oncogene Wnt-3

Synonyms:

INT4 | Proto-oncogene protein Wnt-3 | WNT3 | WNT3_HUMAN

Type:

PROTEIN

Mol. Mass.:

39653.31

Organism:

Homo sapiens (Human)

Description:

ChEMBL_576549

Residue:

355

Sequence:

MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCR
NYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIAS
AGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRP
DARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDS
ASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTC
NVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK

BDBM50294822

n/a

Name

BDBM50294822

Synonyms:

4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-3-methoxy-N-quinolin-8-yl-benzamide | CHEMBL549766

Type

Small organic molecule

Emp. Form.

C26H21N3O4

Mol. Mass.

439.4626

SMILES

COc1cc(ccc1-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O)C(=O)Nc1cccc2cccnc12 |r,wU:14.14,12.13,c:16,(18.67,-31.94,;17.9,-33.27,;18.66,-34.61,;20.2,-34.62,;20.97,-35.95,;20.2,-37.29,;18.66,-37.29,;17.89,-35.95,;16.35,-35.94,;15.44,-37.2,;15.91,-38.67,;13.97,-36.72,;12.62,-37.38,;13.04,-35.9,;12.65,-34.41,;11.31,-35.17,;11.31,-36.71,;13.97,-35.18,;15.44,-34.71,;15.91,-33.24,;22.51,-35.96,;23.28,-34.63,;23.27,-37.3,;24.81,-37.26,;25.56,-35.91,;27.09,-35.86,;27.9,-37.17,;27.16,-38.54,;27.96,-39.84,;27.23,-41.19,;25.69,-41.23,;24.89,-39.92,;25.62,-38.57,)|

Structure