Ki Summary

Reaction Details

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Target

Proto-oncogene Wnt-3

Ligand

BDBM50294827

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_576549 (CHEMBL1032002)

EC50

400±n/a nM

Citation

Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett19:3825-7 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Proto-oncogene Wnt-3

Name:

Proto-oncogene Wnt-3

Synonyms:

INT4 | Proto-oncogene protein Wnt-3 | WNT3 | WNT3_HUMAN

Type:

PROTEIN

Mol. Mass.:

39653.31

Organism:

Homo sapiens (Human)

Description:

ChEMBL_576549

Residue:

355

Sequence:

MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCR
NYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIAS
AGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRP
DARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDS
ASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTC
NVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK

BDBM50294827

n/a

Name

BDBM50294827

Synonyms:

4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-cyclohexanecarboxylic acid quinolin-8-ylamide | CHEMBL564783

Type

Small organic molecule

Emp. Form.

C25H25N3O3

Mol. Mass.

415.4843

SMILES

O=C(Nc1cccc2cccnc12)[C@H]1CC[C@@H](CC1)N1C(=O)[C@H]2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O |r,wU:23.26,25.27,13.14,wD:16.21,22.24,28.33,c:29,(23.31,2.86,;22.53,1.53,;23.3,.19,;24.84,.19,;25.62,1.52,;27.17,1.52,;27.93,.18,;27.16,-1.15,;27.93,-2.48,;27.17,-3.81,;25.62,-3.82,;24.85,-2.48,;25.62,-1.15,;20.99,1.53,;20.23,.2,;18.69,.2,;17.91,1.54,;18.69,2.87,;20.23,2.87,;16.37,1.54,;15.47,2.78,;15.94,4.25,;14,2.3,;12.68,3.07,;13.06,1.59,;12.65,.11,;11.33,.77,;11.34,2.31,;14,.76,;15.46,.29,;15.94,-1.18,)|

Structure