Reaction Details | |||
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Target | Proto-oncogene Wnt-3 | ||
Ligand | BDBM50294832 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_576549 (CHEMBL1032002) | ||
EC50 | >25000±n/a nM | ||
Citation | Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett19:3825-7 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Proto-oncogene Wnt-3 | |||
Name: | Proto-oncogene Wnt-3 | ||
Synonyms: | INT4 | Proto-oncogene protein Wnt-3 | WNT3 | WNT3_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 39653.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_576549 | ||
Residue: | 355 | ||
Sequence: |
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BDBM50294832 | |||
n/a | |||
Name | BDBM50294832 | ||
Synonyms: | 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-ylmethyl)-cyclohexanecarboxylic acid(4-methyl-quinolin-8-yl)-amide | CHEMBL561913 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H29N3O3 | ||
Mol. Mass. | 443.5375 | ||
SMILES | Cc1ccnc2c(NC(=O)[C@H]3CC[C@H](CN4C(=O)[C@H]5[C@@H]6C[C@@H](C=C6)[C@H]5C4=O)CC3)cccc12 |r,wU:19.19,21.20,10.9,wD:13.13,18.17,24.26,c:22,(7.79,-38.19,;6.46,-37.4,;5.12,-38.16,;3.78,-37.38,;3.8,-35.83,;5.15,-35.08,;5.16,-33.53,;3.83,-32.74,;3.85,-31.2,;5.2,-30.45,;2.53,-30.42,;1.19,-31.17,;-.13,-30.39,;-.11,-28.84,;-1.44,-28.05,;-2.97,-28.05,;-3.88,-26.82,;-3.4,-25.35,;-5.34,-27.29,;-6.67,-26.52,;-6.28,-28.01,;-6.7,-29.49,;-8.01,-28.82,;-8.01,-27.28,;-5.35,-28.83,;-3.88,-29.31,;-3.41,-30.78,;1.23,-28.09,;2.56,-28.88,;6.51,-32.78,;7.83,-33.57,;7.81,-35.11,;6.47,-35.87,)| | ||
Structure |