| Reaction Details |
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 | Report a problem with these data |
| Target | NAD kinase |
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| Ligand | BDBM50295362 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_578493 (CHEMBL1063152) |
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| IC50 | 45000±n/a nM |
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| Citation |  Petrelli, R; Sham, YY; Chen, L; Felczak, K; Bennett, E; Wilson, D; Aldrich, C; Yu, JS; Cappellacci, L; Franchetti, P; Grifantini, M; Mazzola, F; Di Stefano, M; Magni, G; Pankiewicz, KW Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues. Bioorg Med Chem17:5656-64 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD kinase |
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| Name: | NAD kinase |
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| Synonyms: | Inorganic polyphosphate/ATP-NAD kinase | NADK_MYCTU | ppnK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32896.75 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_578493 |
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| Residue: | 307 |
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| Sequence: | MTAHRSVLLVVHTGRDEATETARRVEKVLGDNKIALRVLSAEAVDRGSLHLAPDDMRAMG
VEIEVVDADQHAADGCELVLVLGGDGTFLRAAELARNASIPVLGVNLGRIGFLAEAEAEA
IDAVLEHVVAQDYRVEDRLTLDVVVRQGGRIVNRGWALNEVSLEKGPRLGVLGVVVEIDG
RPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTSPEAT
IAIEIEADGHDALVFCDGRREMLIPAGSRLEVTRCVTSVKWARLDSAPFTDRLVRKFRLP
VTGWRGK
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| BDBM50295362 |
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| n/a |
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| Name | BDBM50295362 |
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| Synonyms: | (2S,3S,4R,5R,2'S,3'S,4'R,5'R)-2,2'-[DITHIOBIS(METHYLENE)]BIS[5-(6-AMINO-9H-PURIN-9-YL)TETRAHYDROFURAN-3,4-DIOL] | CHEMBL561654 | di(adenosin-5'-yl)disulfide |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N10O6S2 |
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| Mol. Mass. | 564.598 |
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| SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CSSC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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