| Reaction Details |
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 | Report a problem with these data |
| Target | Melatonin receptor type 1B |
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| Ligand | BDBM50295870 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_578754 (CHEMBL1052327) |
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| Ki | 63±n/a nM |
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| Citation |  Markl, C; Attia, MI; Julius, J; Sethi, S; Witt-Enderby, PA; Zlotos, DP Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands. Bioorg Med Chem17:4583-94 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melatonin receptor type 1B |
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| Name: | Melatonin receptor type 1B |
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| Synonyms: | MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 40203.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49286 |
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| Residue: | 362 |
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| Sequence: | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
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| BDBM50295870 |
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| n/a |
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| Name | BDBM50295870 |
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| Synonyms: | CHEMBL563847 | N-{2-(5-Methoxy-2-({[methyl[4-(trifluoromethyl)phenyl]amino}]-methyl)-1H-indol-3-yl)]ethyl}acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24F3N3O2 |
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| Mol. Mass. | 419.4401 |
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| SMILES | COc1ccc2[nH]c(CN(C)c3ccc(cc3)C(F)(F)F)c(CCNC(C)=O)c2c1 |
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| Structure | 
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