| Reaction Details |
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 | Report a problem with these data |
| Target | Replicative DNA helicase |
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| Ligand | BDBM50295892 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_578771 (CHEMBL1052344) |
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| IC50 | 700±n/a nM |
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| Citation |  Aiello, D; Barnes, MH; Biswas, EE; Biswas, SB; Gu, S; Williams, JD; Bowlin, TL; Moir, DT Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases. Bioorg Med Chem17:4466-76 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Replicative DNA helicase |
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| Name: | Replicative DNA helicase |
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| Synonyms: | DnaC helicase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52545.35 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_578771 |
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| Residue: | 466 |
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| Sequence: | MDRMYEQNQMPHNNEAEQSVLGSIIIDPELINTTQEVLLPESFYRGAHQHIFRAMMHLNE
DNKEIDVVTLMDQLSTEGTLNEAGGPQYLAELSTNVPTTRNVQYYTDIVSKHALKRRLIQ
TADSIANDGYNDELELDAILSDAERRILELSSSRESDGFKDIRDVLGQVYETAEELDQNS
GQTPGIPTGYRDLDQMTAGFNRNDLIILAARPSVGKTAFALNIAQKVATHEDMYTVGIFS
LEMGADQLATRMICSSGNVDSNRLRTGTMTEEDWSRFTIAVGKLSRTKIFIDDTPGIRIN
DLRSKCRRLKQEHGLDMIVIDYLQLIQGSGSRASDNRQQEVSEISRTLKALARELKCPVI
ALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDDYYNRGGDEDDDDDGGFEP
QTNDENGEIEIIIAKQRNGPTGTVKLHFMKQYNKFTDIDYAHADMM
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| BDBM50295892 |
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| n/a |
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| Name | BDBM50295892 |
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| Synonyms: | (Z)-5-(4-hydroxy-3,5-dimethoxybenzylidene)-3-(4-nitrophenyl)-2-thioxothiazolidin-4-one | CHEMBL561122 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N2O6S2 |
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| Mol. Mass. | 418.444 |
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| SMILES | COc1cc(\C=C2/SC(=S)N(C2=O)c2ccc(cc2)[N+]([O-])=O)cc(OC)c1O |
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| Structure | 
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