| Reaction Details |
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 | Report a problem with these data |
| Target | Transporter |
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| Ligand | BDBM50297077 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_581626 (CHEMBL1063375) |
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| Ki | 3.9±n/a nM |
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| Citation |  Fish, PV; Wakenhut, F; Ryckmans, T; Stobie, A Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template. Bioorg Med Chem Lett19:4579-83 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transporter |
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| Name: | Transporter |
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| Synonyms: | NE transporter | NET | Norepinephrine transporter(NET) |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 69236.90 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Q63380 |
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| Residue: | 617 |
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| Sequence: | MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWG
KEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAW
NSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFA
IFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHL
VAQRDVRQFQLRHWLAI
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| BDBM50297077 |
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| n/a |
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| Name | BDBM50297077 |
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| Synonyms: | (S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(trifluoromethyl)benzamide | CHEMBL552338 | PF-3409409 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H21F3N2O |
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| Mol. Mass. | 326.3566 |
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| SMILES | FC(F)(F)c1ccccc1C(=O)N(CC1CCC1)[C@H]1CCNC1 |r| |
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| Structure | 
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