| Reaction Details |
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 | Report a problem with these data |
| Target | Equilibrative nucleoside transporter 1 |
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| Ligand | BDBM50301066 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_598360 (CHEMBL1037264) |
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| IC50 | 1.4±n/a nM |
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| Citation |  Zlatopolskiy, BD; Morgenroth, A; Urusova, EA; Dinger, C; Kull, T; Pape, M; Glatting, G; Reske, SN Towards to hENT1-nucleoside transporter selective imaging agents. Synthesis and in vitro evaluation of the radiolabeled SAENTA analogues. Bioorg Med Chem Lett19:5151-4 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Equilibrative nucleoside transporter 1 |
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| Name: | Equilibrative nucleoside transporter 1 |
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| Synonyms: | ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 50225.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 456 |
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| Sequence: | MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
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| BDBM50301066 |
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| n/a |
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| Name | BDBM50301066 |
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| Synonyms: | CHEMBL571939 | N-(6-(2-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(4-nitrobenzylamino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methylthio)ethylamino)-6-oxohexyl)-3-iodobenzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C32H37IN8O7S |
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| Mol. Mass. | 804.655 |
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| SMILES | O[C@@H]1[C@@H](CSCCNC(=O)CCCCCNC(=O)c2cccc(I)c2)O[C@H]([C@@H]1O)n1cnc2c(NCc3ccc(cc3)[N+]([O-])=O)ncnc12 |r| |
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| Structure | 
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