Ki Summary

Reaction Details

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Target

Cytosolic endo-beta-N-acetylglucosaminidase

Ligand

BDBM50304532

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_604110 (CHEMBL1041618)

1.25±n/a nM

Citation

Usuki, H; Toyo-oka, M; Kanzaki, H; Okuda, T; Nitoda, T Pochonicine, a polyhydroxylated pyrrolizidine alkaloid from fungus Pochonia suchlasporia var. suchlasporia TAMA 87 as a potent beta-N-acetylglucosaminidase inhibitor. Bioorg Med Chem17:7248-53 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cytosolic endo-beta-N-acetylglucosaminidase

Name:

Cytosolic endo-beta-N-acetylglucosaminidase

Synonyms:

ENASE_HUMAN | ENGASE | Endo-beta-N-acetylglucosaminidase

Type:

PROTEIN

Mol. Mass.:

83989.32

Organism:

Homo sapiens (Human)

Description:

ChEMBL_467019

Residue:

743

Sequence:

MEAAAVTVTRSATRRRRRQLQGLAAPEAGTQEEQEDQEPRPRRRRPGRSIKDEEEETVFR
EVVSFSPDPLPVRYYDKDTTKPISFYLSSLEELLAWKPRLEDGFNVALEPLACRQPPLSS
QRPRTLLCHDMMGGYLDDRFIQGSVVQTPYAFYHWQCIDVFVYFSHHTVTIPPVGWTNTA
HRHGVCVLGTFITEWNEGGRLCEAFLAGDERSYQAVADRLVQITQFFRFDGWLINIENSL
SLAAVGNMPPFLRYLTTQLHRQVPGGLVLWYDSVVQSGQLKWQDELNQHNRVFFDSCDGF
FTNYNWREEHLERMLGQAGERRADVYVGVDVFARGNVVGGRFDTDKSLELIRKHGFSVAL
FAPGWVYECLEKKDFFQNQDKFWGRLERYLPTHSICSLPFVTSFCLGMGARRVCYGQEEA
VGPWYHLSAQEIQPLFGEHRLGGDGRGWVRTHCCLEDAWHGGSSLLVRGVIPPEVGNVAV
RLFSLQAPVPPKIYLSMVYKLEGPTDVTVALELTTGDAGSCHIGGISVLNAETSSRHSLR
PLRVPPTKLARWVGRCGRQLSGGWVQHCYEVSLRGCLLLDLLVCFSRPPGSREEESFTCR
LGEIQVVDAASLLAPLPQVQAVTISHIRWQPSASEREGPPALLQLSCTLHWSFLLSQVRC
FRIHCWGGMSDDSPGRELPRPEMPMFLGLAFATQYRIVDLLVEAAGPGQDRRMEFLVEPV
PKEGFRVPQAEWGRAVLLYSAPA

BDBM50304532

n/a

Name

BDBM50304532

Synonyms:

(1R*, 3S*, 5S*, 6S*, 7R*, 7a S*)-5-acetamidomethyl-3-hydroxymethyl-1,6,7-trihydroxypyrrolizidine | CHEMBL593689

Type

Small organic molecule

Emp. Form.

C11H20N2O5

Mol. Mass.

260.2869

SMILES

CC(=O)NC[C@H]1[C@H](O)[C@H](O)[C@@H]2[C@H](O)C[C@@H](CO)N12 |r|

Structure