Reaction Details |
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Target | Cytochrome P450 11B1, mitochondrial |
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Ligand | BDBM50188088 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_610341 (CHEMBL1072073) |
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IC50 | 211±n/a nM |
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Citation | Roumen, L; Peeters, JW; Emmen, JM; Beugels, IP; Custers, EM; de Gooyer, M; Plate, R; Pieterse, K; Hilbers, PA; Smits, JF; Vekemans, JA; Leysen, D; Ottenheijm, HC; Janssen, HM; Hermans, JJ Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem53:1712-25 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 11B1, mitochondrial |
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Name: | Cytochrome P450 11B1, mitochondrial |
Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
Type: | Enzyme |
Mol. Mass.: | 57591.44 |
Organism: | Homo sapiens (Human) |
Description: | P15538 |
Residue: | 503 |
Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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BDBM50188088 |
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n/a |
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Name | BDBM50188088 |
Synonyms: | 1-(4-bromobenzyl)-1H-imidazole | CHEMBL211207 |
Type | Small organic molecule |
Emp. Form. | C10H9BrN2 |
Mol. Mass. | 237.096 |
SMILES | Brc1ccc(Cn2ccnc2)cc1 |
Structure |
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