| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 1 |
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| Ligand | BDBM50307264 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_610615 (CHEMBL1069629) |
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| IC50 | 4000±n/a nM |
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| Citation |  Ravindranathan, KP; Mandiyan, V; Ekkati, AR; Bae, JH; Schlessinger, J; Jorgensen, WL Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening. J Med Chem53:1662-72 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 1 |
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| Name: | Fibroblast growth factor receptor 1 |
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| Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr |
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| Type: | Receptor |
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| Mol. Mass.: | 91861.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11362 |
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| Residue: | 822 |
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| Sequence: | MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD
ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD
KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF
PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
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| BDBM50307264 |
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| n/a |
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| Name | BDBM50307264 |
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| Synonyms: | 2-[4-(1,4-dihydro-7-methyl-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl)-2-methoxyphenoxy]-acetic acid | CHEMBL596972 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16N2O5S |
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| Mol. Mass. | 396.416 |
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| SMILES | COc1cc(ccc1OCC(O)=O)-c1nc2sc3cc(C)ccc3c2c(=O)[nH]1 |
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| Structure | 
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