| Reaction Details |
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 | Report a problem with these data |
| Target | Secreted frizzled-related protein 1 |
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| Ligand | BDBM50308711 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_607291 (CHEMBL1072833) |
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| IC50 | 20±n/a nM |
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| Citation |  Moore, WJ; Kern, JC; Bhat, R; Bodine, PV; Fukyama, S; Krishnamurthy, G; Magolda, RL; Pitts, K; Stauffer, B; Trybulski, EJ Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg Med Chem18:190-201 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Secreted frizzled-related protein 1 |
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| Name: | Secreted frizzled-related protein 1 |
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| Synonyms: | FRP | FRP1 | SARP2 | SFRP1 | SFRP1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35404.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1363191 |
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| Residue: | 314 |
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| Sequence: | MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVD
IPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPV
CLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKP
QGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKK
KDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKK
MKNHECPTFQSVFK
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| BDBM50308711 |
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| n/a |
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| Name | BDBM50308711 |
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| Synonyms: | 4-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]sulfonyl}benzoic acid | CHEMBL592214 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23F3N2O8S3 |
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| Mol. Mass. | 632.649 |
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| SMILES | OC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |
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| Structure | 
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