| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Telomerase reverse transcriptase |
|---|
| Ligand | BDBM50080851 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_622825 (CHEMBL1105835) |
|---|
| IC50 | 8200±n/a nM |
|---|
| Citation |  Castillo-González, D; Cabrera-Pérez, MA; Pérez-González, M; Morales Helguera, A; Durán-Martínez, A Prediction of telomerase inhibitory activity for acridinic derivatives based on chemical structure. Eur J Med Chem44:4826-40 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Telomerase reverse transcriptase |
|---|
| Name: | Telomerase reverse transcriptase |
|---|
| Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 127099.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1447029 |
|---|
| Residue: | 1132 |
|---|
| Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
|
|
|
|---|
| BDBM50080851 |
|---|
| n/a |
|---|
| Name | BDBM50080851 |
|---|
| Synonyms: | 3-Dimethylamino-N-[6-(3-dimethylamino-propionylamino)-acridin-3-yl]-propionamide | CHEMBL311072 | N,N'-(acridine-3,6-diyl)bis(3-(dimethylamino)propanamide) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H29N5O2 |
|---|
| Mol. Mass. | 407.5087 |
|---|
| SMILES | CN(C)CCC(=O)Nc1ccc2cc3ccc(NC(=O)CCN(C)C)cc3nc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
