| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear factor NF-kappa-B p105 subunit |
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| Ligand | BDBM50311740 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_618971 (CHEMBL1100041) |
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| IC50 | >20000±n/a nM |
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| Citation |  Han, AR; Kim, JA; Lantvit, DD; Kardono, LB; Riswan, S; Chai, H; Carcache de Blanco, EJ; Farnsworth, NR; Swanson, SM; Kinghorn, AD Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen). J Nat Prod72:2028-31 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear factor NF-kappa-B p105 subunit |
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| Name: | Nuclear factor NF-kappa-B p105 subunit |
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| Synonyms: | NFKB1 | NFKB1_HUMAN | Nuclear factor NF-kappa-B (NF-kB) | Nuclear factor NF-kappa-B complex | Nuclear factor NF-kappa-B p105 subunit |
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| Type: | Protein |
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| Mol. Mass.: | 105329.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P19838 |
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| Residue: | 968 |
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| Sequence: | MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV
CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED
GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA
EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY
DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF
SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ
RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH
PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE
VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD
ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED
LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM
SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT
TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT
SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG
LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ
AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ
EGPLEGKI
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| BDBM50311740 |
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| n/a |
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| Name | BDBM50311740 |
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| Synonyms: | 11-hydroxy-1-isomangostin | CHEMBL1080697 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26O7 |
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| Mol. Mass. | 426.459 |
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| SMILES | [#6]-[#8]-c1c(-[#8])cc2oc3cc(-[#8])c4-[#6]-[#6](-[#8])C([#6])([#6])[#8]-c4c3c(=O)c2c1-[#6]\[#6]=[#6](\[#6])-[#6] |
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| Structure | 
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