Ki Summary

Reaction Details

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Target

IgG receptor FcRn large subunit p51

Ligand

BDBM50314079

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_627629 (CHEMBL1114459)

IC50

1100±n/a nM

Citation

McDonnell, KA; Low, SC; Hoehn, T; Donnelly, R; Palmieri, H; Fraley, C; Sakorafas, P; Mezo, AR Synthesis and structure-activity relationships of dimeric peptide antagonists of the human immunoglobulin G-human neonatal Fc receptor (IgG-FcRn) interaction. J Med Chem53:1587-96 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

IgG receptor FcRn large subunit p51

Name:

IgG receptor FcRn large subunit p51

Synonyms:

FCGRN_HUMAN | FCGRT | FCRN

Type:

PROTEIN

Mol. Mass.:

39742.86

Organism:

Homo sapiens (Human)

Description:

ChEMBL_627631

Residue:

365

Sequence:

MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLS
YNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCE
LGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLF
SCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGL
AAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLV
VGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNV
IPATA

BDBM50314079

n/a

Name

BDBM50314079

Synonyms:

(5S,8S,15S,18R,23R,26S,32S,35S,38S)-35-benzyl-23-[(2S)-2-[(2S)-5-carbamimidamido-2-acetamidopentanamido]-3-phenylpropanamido]-8-[(4-hydroxyphenyl)methyl]-32-(1H-imidazol-4-ylmethyl)-4,22,22,25,26-pentamethyl-5-(2-methylpropyl)-3,6,9,10,16,24,27,30,33,36,42-undecaoxo-20,21-dithia-1,4,7,11,17,25,28,31,34,37-decaazatricyclo[36.3.1.0^{11,15}]dotetracontane-18-carboxamide | CHEMBL1089947

Type

Small organic molecule

Emp. Form.

C75H103N19O16S2

Mol. Mass.

1590.868

SMILES

CC(C)C[C@@H]1N(C)C(=O)CN2CCC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC(=O)[C@H](C)N(C)C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(C)(C)SSC[C@H](NC(=O)[C@@H]3CCCN3C(=O)C(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(N)=O)C2=O |r|

Structure