| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50316216 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_628258 (CHEMBL1111846) |
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| IC50 | 4000±n/a nM |
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| Citation |  Malviya, M; Kumar, YC; Mythri, RB; Venkateshappa, C; Subhash, MN; Rangappa, KS Muscarinic receptor 1 agonist activity of novel N-aryl carboxamide substituted 3-morpholino arecoline derivatives in Alzheimer's presenile dementia models. Bioorg Med Chem17:5526-34 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51390.46 |
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| Organism: | RAT |
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| Description: | P08482 |
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| Residue: | 460 |
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| Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50316216 |
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| n/a |
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| Name | BDBM50316216 |
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| Synonyms: | (4-Chlorophenyl)(2-(1,2,5,6-tetrahydro-1-methylpyridin-3-yl)-morpholino)methanone | CHEMBL1095288 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H21ClN2O2 |
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| Mol. Mass. | 320.814 |
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| SMILES | CN1CCC=C(C1)C1CN(CCO1)C(=O)c1ccc(Cl)cc1 |c:4| |
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| Structure | 
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