| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50316332 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_627830 (CHEMBL1117207) |
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| Ki | 13±n/a nM |
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| Citation |  Czopek, A; Byrtus, H; Kolaczkowski, M; Pawlowski, M; Dybala, M; Nowak, G; Tatarczynska, E; Wesolowska, A; Chojnacka-Wójcik, E Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Novel 5-HT1A receptor agonist with potential antidepressant and anxiolytic activity. Eur J Med Chem45:1295-303 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46445.29 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Binding assays were performed using rat hippocampal membranes. |
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| Residue: | 422 |
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| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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| BDBM50316332 |
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| n/a |
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| Name | BDBM50316332 |
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| Synonyms: | CHEMBL1095934 | rac-5-Cyclopropyl-5-phenyl-3-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-imidazolidine-2,4-dione |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29ClN4O2 |
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| Mol. Mass. | 452.976 |
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| SMILES | Clc1cccc(c1)N1CCN(CCCN2C(=O)NC(C3CC3)(C2=O)c2ccccc2)CC1 |
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| Structure | 
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