| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Anthranilate synthase component 1 |
|---|
| Ligand | BDBM50317144 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_630882 (CHEMBL1113011) |
|---|
| Ki | 1020000±n/a nM |
|---|
| Citation |  Ziebart, KT; Dixon, SM; Avila, B; El-Badri, MH; Guggenheim, KG; Kurth, MJ; Toney, MD Targeting multiple chorismate-utilizing enzymes with a single inhibitor: validation of a three-stage design. J Med Chem53:3718-29 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Anthranilate synthase component 1 |
|---|
| Name: | Anthranilate synthase component 1 |
|---|
| Synonyms: | TRPE_SALTY | trpE |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 57080.90 |
|---|
| Organism: | Salmonella typhimurium |
|---|
| Description: | ChEMBL_630882 |
|---|
| Residue: | 520 |
|---|
| Sequence: | MQTPKPTLELLTCDAAYRENPTALFHQVCGDRPATLLLESADIDSKDDLKSLLLVDSALR
ITALGDTVTIQALSDNGASLLPLLDTALPAGVENDVLPAGRVLRFPPVSPLLDEDARLCS
LSVFDAFRLLQGVVNIPTQEREAMFFGGLFAYDLVAGFEALPHLEAGNNCPDYCFYLAET
LMVIDHQKKSTRIQASLFTASDREKQRLNARLAYLSQQLTQPAPPLPVTPVPDMRCECNQ
SDDAFGAVVRQLQKAIRAGEIFQVVPSRRFSLPCPSPLAAYYVLKKSNPSPYMFFMQDND
FTLFGASPESSLKYDAASRQIEIYPIAGTRPRGRRADGTLDRDLDSRIELDMRTDHKELS
EHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLVSRVVGELRHDLDALHAYRAC
MNMGTLSGAPKVRAMQLIADAEGQRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATV
QAGAGIVLDSVPQSEADETRNKARAVLRAIATAHHAQETF
|
|
|
|---|
| BDBM50317144 |
|---|
| n/a |
|---|
| Name | BDBM50317144 |
|---|
| Synonyms: | CHEMBL1094071 | {3-[(S)-4-(4-Carbamoyl-1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-ylcarbamoyl)-4-(4-phenoxy-benzoylamino)-butylcarbamoyl]-phenoxy}-acetic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H36N4O10S |
|---|
| Mol. Mass. | 680.725 |
|---|
| SMILES | NC(=O)C1(CCS(=O)(=O)CC1)NC(=O)[C@H](CCCNC(=O)c1cccc(OCC(O)=O)c1)NC(=O)c1ccc(Oc2ccccc2)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
