Ki Summary

Reaction Details

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Target

Cyclin-dependent kinase 2/G1/S-specific cyclin-E1

Ligand

BDBM50317173

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_631113 (CHEMBL1103822)

IC50

8.7±n/a nM

Citation

Choi, SJ; Lee, JE; Jeong, SY; Im, I; Lee, SD; Lee, EJ; Lee, SK; Kwon, SM; Ahn, SG; Yoon, JH; Han, SY; Kim, JI; Kim, YC 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem53:3696-706 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cyclin-dependent kinase 2/G1/S-specific cyclin-E1

Name:

Cyclin-dependent kinase 2/G1/S-specific cyclin-E1

Synonyms:

Type:

Protein

Mol. Mass.:

n/a

Description:

n/a

Components:

This complex has 2 components.

Component 1

Name:

Cyclin-dependent kinase 2

Synonyms:

Type:

Enzyme Subunit

Mol. Mass.:

33938.17

Organism:

Homo sapiens (Human)

Description:

P24941

Residue:

298

Sequence:

MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Component 2

Name:

G1/S-specific cyclin-E1

Synonyms:

CCNE | CCNE1 | CCNE1_HUMAN

Type:

Enzyme Subunit

Mol. Mass.:

47073.17

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

410

Sequence:

MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ
PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM
LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ
ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR
LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA
ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI
QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA

BDBM50317173

n/a

Name

BDBM50317173

Synonyms:

(2'Z,3'E)-5-Nitro-5'-methyl-indirubin-3'-oxime | CHEMBL1086701

Type

Small organic molecule

Emp. Form.

C17H12N4O4

Mol. Mass.

336.3016

SMILES

Cc1ccc2[nH]c(c(N=[OH+])c2c1)-[c-]1c2cc(ccc2[nH]c1=O)[N+]([O-])=O |(23.35,-22.07,;24.68,-22.84,;24.68,-24.38,;26.01,-25.15,;27.35,-24.38,;28.82,-24.86,;29.73,-23.61,;28.82,-22.35,;29.3,-20.89,;30.8,-20.57,;27.34,-22.83,;26.01,-22.07,;31.27,-23.61,;32.17,-22.36,;31.85,-20.86,;32.98,-19.83,;34.46,-20.3,;34.78,-21.81,;33.64,-22.84,;33.64,-24.38,;32.18,-24.85,;31.7,-26.32,;32.66,-18.33,;33.79,-17.29,;31.19,-17.86,)|

Structure