| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
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| Ligand | BDBM50317920 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_630412 (CHEMBL1113783) |
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| IC50 | 2788±n/a nM |
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| Citation |  Singh, P; Bhardwaj, A Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation. J Med Chem53:3707-17 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 1 |
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| Name: | Prostaglandin G/H synthase 1 |
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| Synonyms: | COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase) |
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| Type: | Protein |
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| Mol. Mass.: | 68868.60 |
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| Organism: | Ovis aries (Sheep) |
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| Description: | n/a |
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| Residue: | 600 |
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| Sequence: | MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCT
RTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVR
SNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRR
FLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLER
QYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLML
YATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLK
FDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVE
ALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQE
LTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPIC
SPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
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| BDBM50317920 |
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| n/a |
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| Name | BDBM50317920 |
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| Synonyms: | (2R*,4R*,6S*)-Tetrahydro-2,4-diphenyl-6-(thiocyanatomethyl)-2H-pyran-4-ol | CHEMBL1096036 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19NO2S |
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| Mol. Mass. | 325.425 |
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| SMILES | O[C@]1(C[C@@H](CSC#N)O[C@H](C1)c1ccccc1)c1ccccc1 |r| |
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| Structure | 
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