| Reaction Details |
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 | Report a problem with these data |
| Target | HTH-type transcriptional regulator ExsA |
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| Ligand | BDBM50319081 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_635526 (CHEMBL1118109) |
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| IC50 | 6700±n/a nM |
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| Citation |  Grier, MC; Garrity-Ryan, LK; Bartlett, VJ; Klausner, KA; Donovan, PJ; Dudley, C; Alekshun, MN; Tanaka, SK; Draper, MP; Levy, SB; Kim, OK N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability. Bioorg Med Chem Lett20:3380-3 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| HTH-type transcriptional regulator ExsA |
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| Name: | HTH-type transcriptional regulator ExsA |
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| Synonyms: | EXSA_PSEAE | Exoenzyme S synthesis regulatory protein exsA | exsA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31648.37 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | ChEMBL_635526 |
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| Residue: | 278 |
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| Sequence: | MQGAKSLGRKQITSCHWNIPTFEYRVNKEEGVYVLLEGELTVQDIDSTFCLAPGELLFVR
RGSYVVSTKGKDSRILWIPLSAQFLQGFVQRFGALLSEVERCDEPVPGIIAFAATPLLAG
CVKGLKELLVHEHPPMLACLKIEELLMLFAFSPQGPLLMSVLRQLSNRHVERLQLFMEKH
YLNEWKLSDFSREFGMGLTTFKELFGSVYGVSPRAWISERRILYAHQLLLNSDMSIVDIA
MEAGFSSQSYFTQSYRRRFGCTPSRSRQGKDECRAKNN
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| BDBM50319081 |
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| n/a |
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| Name | BDBM50319081 |
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| Synonyms: | (E)-N-(4-(1-hydroxy-6-nitro-1H-benzo[d]imidazol-2-yl)phenyl)-3-(6-(trifluoromethyl)pyridin-3-yl)acrylamide | CHEMBL1085377 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H14F3N5O4 |
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| Mol. Mass. | 469.3729 |
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| SMILES | On1c(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(NC(=O)\C=C\c2ccc(nc2)C(F)(F)F)cc1 |
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| Structure | 
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