Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSynaptic vesicular amine transporter
LigandBDBM50080827
Substrate/Competitorn/a
Meas. Tech.ChEMBL_633949 (CHEMBL1117630)
Ki 970±n/a nM
Citation Vartak, AP; Gabriela Deaciuc, A; Dwoskin, LP; Crooks, PA Quinlobelane: a water-soluble lobelane analogue and inhibitor of VMAT2. Bioorg Med Chem Lett20:3584-7 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Synaptic vesicular amine transporter
Name:Synaptic vesicular amine transporter
Synonyms:Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2
Type:Protein
Mol. Mass.:55689.58
Organism:Rattus norvegicus (Rat)
Description:Q01827
Residue:515
Sequence:
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50080827
n/a
NameBDBM50080827
Synonyms:(2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,6R)-1-Methyl-2,6-diphenethyl-piperidine | CHEMBL1085811 | CHEMBL333465 | Lobelane | cis-N-methyl-2,6-diphenethylpiperidine
TypeSmall organic molecule
Emp. Form.C22H29N
Mol. Mass.307.4724
SMILESCN1[C@@H](CCc2ccccc2)CCC[C@H]1CCc1ccccc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: