| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
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| Ligand | BDBM50320883 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_636328 (CHEMBL1169051) |
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| IC50 | 16600±n/a nM |
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| Citation |  Kumar, A; Sharma, S; Tripathi, VD; Maurya, RA; Srivastava, SP; Bhatia, G; Tamrakar, AK; Srivastava, AK Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents. Bioorg Med Chem18:4138-48 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 49963.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion PTP1B (1-435). |
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| Residue: | 435 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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| BDBM50320883 |
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| n/a |
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| Name | BDBM50320883 |
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| Synonyms: | CHEMBL1164164 | Ethyl-4-(4-bromophenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22BrNO3 |
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| Mol. Mass. | 404.298 |
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| SMILES | CCOC(=O)C1=CC(C2C(=O)CC(C)(C)CC2=N1)c1ccc(Br)cc1 |c:17,t:5| |
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| Structure | 
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