| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ITK/TSK |
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| Ligand | BDBM50320993 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_639388 (CHEMBL1167768) |
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| IC50 | >100000±n/a nM |
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| Citation |  Velankar, AD; Quintini, G; Prabhu, A; Weber, A; Hunaeus, G; Voland, B; Wuest, M; Orjeda, C; Harel, D; Varghese, S; Gore, V; Patil, M; Gayke, D; Herdemann, M; Heit, I; Zaliani, A Synthesis and biological evaluation of novel (4 or 5-aryl)pyrazolyl-indoles as inhibitors of interleukin-2 inducible T-cell kinase (ITK). Bioorg Med Chem18:4547-59 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ITK/TSK |
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| Name: | Tyrosine-protein kinase ITK/TSK |
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| Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
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| Type: | Protein |
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| Mol. Mass.: | 71839.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08881 |
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| Residue: | 620 |
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| Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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| BDBM50320993 |
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| n/a |
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| Name | BDBM50320993 |
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| Synonyms: | 3-Hydroxymethyl-2-(4-phenyl-1H-pyrazol-3-yl)-1Hindole-6-carboxylic acid isobutyl-methyl-amide | CHEMBL1164565 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N4O2 |
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| Mol. Mass. | 402.4888 |
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| SMILES | CC(C)CN(C)C(=O)c1ccc2c(CO)c([nH]c2c1)-c1n[nH]cc1-c1ccccc1 |
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| Structure | 
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