| Reaction Details |
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 | Report a problem with these data |
| Target | Polyphenol oxidase 2 |
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| Ligand | BDBM50321280 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_638417 (CHEMBL1167863) |
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| IC50 | >100000±n/a nM |
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| Citation |  Koyama, K; Hirasawa, Y; Hosoya, T; Hoe, TC; Chan, KL; Morita, H Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora. Bioorg Med Chem18:4415-21 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyphenol oxidase 2 |
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| Name: | Polyphenol oxidase 2 |
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| Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
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| Type: | Protein |
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| Mol. Mass.: | 63923.66 |
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| Organism: | Agaricus bisporus (Common mushroom) |
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| Description: | O42713 |
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| Residue: | 556 |
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| Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
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| BDBM50321280 |
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| n/a |
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| Name | BDBM50321280 |
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| Synonyms: | Alpneumine B | CHEMBL1164346 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N2O4 |
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| Mol. Mass. | 354.3997 |
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| SMILES | COC(=O)C1[C@@H]2C[C@H]3N(CC[C@@]33C1=Nc1c3cccc1O)C[C@@H]2C(C)=O |r,t:14| |
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| Structure | 
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