| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50321748 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_641055 (CHEMBL1174296) |
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| IC50 | 52.7±n/a nM |
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| Citation |  Hsieh, PW; Yu, HP; Chang, YJ; Hwang, TL Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats. Eur J Med Chem45:3111-5 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50321748 |
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| n/a |
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| Name | BDBM50321748 |
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| Synonyms: | 5-Chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one | CHEMBL1172305 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H7ClFNO2 |
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| Mol. Mass. | 275.662 |
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| SMILES | Fc1ccccc1-c1nc2cccc(Cl)c2c(=O)o1 |
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| Structure | 
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