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TargetNeutrophil elastase
LigandBDBM50321751
Substrate/Competitorn/a
Meas. Tech.ChEMBL_641056 (CHEMBL1174297)
IC50 48.8±n/a nM
Citation Hsieh, PWYu, HPChang, YJHwang, TL Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats. Eur J Med Chem45:3111-5 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50321751
n/a
NameBDBM50321751
Synonyms:5-Chloro-2-(2-methylphenyl)-4H-benzo[d][1,3]oxazin-4-one | CHEMBL1172306
TypeSmall organic molecule
Emp. Form.C15H10ClNO2
Mol. Mass.271.698
SMILESCc1ccccc1-c1nc2cccc(Cl)c2c(=O)o1
Structure
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