Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50321757 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_641177 (CHEMBL1174684) |
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Ki | 3.3±n/a nM |
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Citation | Oberdorf, C; Schmidt, TJ; Wünsch, B 5D-QSAR for spirocyclic sigma1 receptor ligands by Quasar receptor surface modeling. Eur J Med Chem45:3116-24 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
Type: | Protein |
Mol. Mass.: | 25307.17 |
Organism: | Cavia porcellus (Guinea pig) |
Description: | Q60492 |
Residue: | 223 |
Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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BDBM50321757 |
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n/a |
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Name | BDBM50321757 |
Synonyms: | (R)-(1-benzyl-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-2'-yl)(phenyl)methanone | CHEMBL1171232 |
Type | Small organic molecule |
Emp. Form. | C26H27NO3S |
Mol. Mass. | 433.562 |
SMILES | CO[C@H]1Cc2sc(cc2C2(CCN(Cc3ccccc3)CC2)O1)C(=O)c1ccccc1 |r| |
Structure |
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