Reaction Details |
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Target | Aurora kinase B |
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Ligand | BDBM50324277 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_650024 (CHEMBL1219722) |
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IC50 | 235±n/a nM |
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Citation | Chiang, CC; Lin, YH; Lin, SF; Lai, CL; Liu, C; Wei, WY; Yang, SC; Wang, RW; Teng, LW; Chuang, SH; Chang, JM; Yuan, TT; Lee, YS; Chen, P; Chi, WK; Yang, JY; Huang, HJ; Liao, CB; Huang, JJ Discovery of pyrrole-indoline-2-ones as Aurora kinase inhibitors with a different inhibition profile. J Med Chem53:5929-41 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase B |
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Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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BDBM50324277 |
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n/a |
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Name | BDBM50324277 |
Synonyms: | (Z)-N-[3-({3-[3-(Dimethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)-2-oxoindolin-5-yl]benzenesulfonamide | CHEMBL1215346 |
Type | Small organic molecule |
Emp. Form. | C28H30N4O4S |
Mol. Mass. | 518.627 |
SMILES | CN(C)CCCc1c(C=C2C(=O)Nc3ccc(NS(=O)(=O)c4ccccc4)cc23)[nH]c2CCCC(=O)c12 |w:8.7| |
Structure |
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