| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM50324276 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_650024 (CHEMBL1219722) |
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| IC50 | 310±n/a nM |
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| Citation |  Chiang, CC; Lin, YH; Lin, SF; Lai, CL; Liu, C; Wei, WY; Yang, SC; Wang, RW; Teng, LW; Chuang, SH; Chang, JM; Yuan, TT; Lee, YS; Chen, P; Chi, WK; Yang, JY; Huang, HJ; Liao, CB; Huang, JJ Discovery of pyrrole-indoline-2-ones as Aurora kinase inhibitors with a different inhibition profile. J Med Chem53:5929-41 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM50324276 |
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| n/a |
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| Name | BDBM50324276 |
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| Synonyms: | (Z)-N-[2-Oxo-3-({4-oxo-3-[3-(pyrrolidin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-5-yl]benzenesulfonamide | CHEMBL1215284 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32N4O4S |
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| Mol. Mass. | 544.664 |
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| SMILES | O=C1Nc2ccc(NS(=O)(=O)c3ccccc3)cc2C1=Cc1[nH]c2CCCC(=O)c2c1CCCN1CCCC1 |w:20.23| |
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| Structure | 
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