| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-1 |
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| Ligand | BDBM50324958 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_651546 (CHEMBL1227798) |
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| Ki | 18.7±n/a nM |
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| Citation |  Galatsis, P; Caprathe, B; Gilmore, J; Thomas, A; Linn, K; Sheehan, S; Harter, W; Kostlan, C; Lunney, E; Stankovic, C; Rubin, J; Brady, K; Allen, H; Talanian, R Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1). Bioorg Med Chem Lett20:5184-90 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-1 |
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| Name: | Caspase-1 |
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| Synonyms: | CASP1_MOUSE | Casp1 | Il1bc |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45636.44 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_651546 |
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| Residue: | 402 |
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| Sequence: | MADKILRAKRKQFINSVSIGTINGLLDELLEKRVLNQEEMDKIKLANITAMDKARDLCDH
VSKKGPQASQIFITYICNEDCYLAGILELQSAPSAETFVATEDSKGGHPSSSETKEEQNK
EDGTFPGLTGTLKFCPLEKAQKLWKENPSEIYPIMNTTTRTRLALIICNTEFQHLSPRVG
AQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQE
GICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVRD
SEEDFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAW
SCDLEDIFRKVRFSFEQPEFRLQMPTADRVTLTKRFYLFPGH
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| BDBM50324958 |
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| n/a |
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| Name | BDBM50324958 |
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| Synonyms: | (S)-3-((S)-2-isopropyl-4-(2-(2-methyl-1H-benzo[d]imidazol-1-yl)ethylamino)-4-oxobutanamido)-4-oxobutanoic acid | CHEMBL1221689 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28N4O5 |
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| Mol. Mass. | 416.4708 |
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| SMILES | CC(C)[C@H](CC(=O)NCCn1c(C)nc2ccccc12)C(=O)N[C@@H](CC(O)=O)C=O |r| |
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| Structure | 
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