| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thymidylate synthase |
|---|
| Ligand | BDBM50326711 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_661530 (CHEMBL1253094) |
|---|
| Ki | 260±n/a nM |
|---|
| Citation |  Garg, D; Henrich, S; Salo-Ahen, OM; Myllykallio, H; Costi, MP; Wade, RC Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs. J Med Chem53:6539-49 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thymidylate synthase |
|---|
| Name: | Thymidylate synthase |
|---|
| Synonyms: | TS | TSase | TYMS | TYSY_HUMAN | Thymidylate synthase (TS) | Thymidylate synthase/GAR transformylase/AICAR transformylase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 35718.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 313 |
|---|
| Sequence: | MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
|
|
|
|---|
| BDBM50326711 |
|---|
| n/a |
|---|
| Name | BDBM50326711 |
|---|
| Synonyms: | 1,3-propanediphosphonic acid | CHEMBL1230579 | PROPANE-1,3-DIYLBIS(PHOSPHONIC ACID) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C3H10O6P2 |
|---|
| Mol. Mass. | 204.0554 |
|---|
| SMILES | OP(O)(=O)CCCP(O)(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
