| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Macrophage migration inhibitory factor |
|---|
| Ligand | BDBM50327348 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_664389 (CHEMBL1259538) |
|---|
| IC50 | 7.5±n/a nM |
|---|
| Citation |  Hare, AA; Leng, L; Gandavadi, S; Du, X; Cournia, Z; Bucala, R; Jorgensen, WL Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF). Bioorg Med Chem Lett20:5811-4 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Macrophage migration inhibitory factor |
|---|
| Name: | Macrophage migration inhibitory factor |
|---|
| Synonyms: | GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 12478.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14174 |
|---|
| Residue: | 115 |
|---|
| Sequence: | MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALC
SLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
|
|
|
|---|
| BDBM50327348 |
|---|
| n/a |
|---|
| Name | BDBM50327348 |
|---|
| Synonyms: | 3-(3-hydroxybenzyl)-6-methylbenzo[d]oxazol-2(3H)-one | CHEMBL1256233 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H13NO3 |
|---|
| Mol. Mass. | 255.2686 |
|---|
| SMILES | Cc1ccc2n(Cc3cccc(O)c3)c(=O)oc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
