| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-S-isoprenylcysteine O-methyltransferase |
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| Ligand | BDBM50327705 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_664824 (CHEMBL1259548) |
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| IC50 | 2500±n/a nM |
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| Citation |  Go, ML; Leow, JL; Gorla, SK; Schüller, AP; Wang, M; Casey, PJ Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase. J Med Chem53:6838-50 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-S-isoprenylcysteine O-methyltransferase |
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| Name: | Protein-S-isoprenylcysteine O-methyltransferase |
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| Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31943.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_956034 |
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| Residue: | 284 |
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| Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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| BDBM50327705 |
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| n/a |
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| Name | BDBM50327705 |
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| Synonyms: | 2-(1-(3-(trifluoromethyl)benzyl)-5-m-tolyl-1H-indol-3-yl)acetamide | 2-(5-m-tolyl-1-(3-(trifluoromethyl)benzyl)-1H-indol-3-yl)acetamide | CHEMBL241264 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21F3N2O |
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| Mol. Mass. | 422.4422 |
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| SMILES | Cc1cccc(c1)-c1ccc2n(Cc3cccc(c3)C(F)(F)F)cc(CC(N)=O)c2c1 |
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| Structure | 
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